Proventil Inhaler Composition
The composition of one metered aerosol for inhalation include salbutamol sulphate 124 mg, corresponding to 100 mg of pure material. Ethanol and hydrofluoroalkane are used as additive agents.
- each tablet may contain 2 or 4 mg of active substance in tablets – 4 mg (children) and 8 mg (adults);
- one dose of powder for inhalation contains 200 or 400 micrograms of albuterol;
- syrup for oral administration – 0.4 mg / ml;
- solution for inhalation application – 1.25 mg / ml;
- injection solution – 0.1 mg / ml.
Salbutamol has the following formulations:
- metered aerosol for inhalation of 100 mg per dose (manufactured in aluminum cans at a pressure of 200 doses each inhaler, when sprayed onto a glass surface its contents leave white spot);
- metered powder for inhalation of 200 or 400 mcg / dose;
- film coated tablet of 2 and 4 mg.
Proventil inhaler is produced under various brand names and can also take form of:
- retard tablets;
- solution for inhalation;
- injectable solution;
- infusion solution concentrate;
- capsules filled with powder for inhalation application.
Proventil online is bronchodilatory agent, selective β2-adrenoagonists (selective antagonist of β2-adrenergic receptors). Pharmacological drug action: bronchodilator and tocolytic.
Pharmacodynamics and Pharmacokinetics
When used in therapeutic doses it has pronounced effect of bronchodilators, prevents and relieves bronchospastic syndrome, increases lung capacity, makes it difficult to release into extracellular space of histamine, chemotactic factors, slow-reacting substance and number of other highly active substances.
On Proventil generic inhaler background slight positive foreign-and chronotropic effects on cardiac muscle are showed.
This inhaler contributes to coronary arteries expansion, suppression of early and late bronchial reactivity, reduces resistance in respiratory tract, as well as tone and contractile activity of myometrium, improves function of bronchial ciliated epithelium, stimulates expectoration and mucus production.
This means virtually has no effect on β1-adrenergic receptors, does not cause blood pressure decrease and, in comparison with others Proventil online has much less effect on the heart being similar in other drugs mechanism of action.
Proventil inhaler for asthma also has metabolic effects: reduces potassium concentration in blood plasma, affects process of splitting glucose to glycogen (glycogenolysis) and insulin secretion.
For some patients (especially for patients with bronchial asthma) it is able to provide hyperglycemic and lipolytic effects, thereby increasing risk of ketoacidotic coma.
After inhaled drugs forms administration effect begins developing after 5 minutes and reaches its maximum in approximately 75% of patients for 30-90 minutes.
Proventil Inhaler Indications for Use
Indications for albuterol use are:
- bronchial asthma (tis means can be used for relief of bronchospastic syndrome, and to prevent it);
- chronical bronchitis;
- asthmatic bronchitis;
- uncomplicated premature labor.
In pediatrics Proventil is also used to treat bronchospastic syndrome.
The use of Albuterol is contraindicated in the following cases:
- hypersensitivity to drug and its components;
- cardiac arrhythmia (for example, polymorphic ventricular premature beats or paroxysmal tachycardia);
- heart disorders;
- aortic stenosis;
- coronary heart disease;
- decompensated diabetes;
- pyloroduodenal narrowing;
- liver and / or kidney failure;
The drug is not indicated in combination with non-selective β-blockers, as well as for treatment of children up to 2 years.
It should be used with caution in case of:
- severe chronic heart failure;
- arterial hypertension.
Intravenous Proventil is contraindicated in:
- intrauterine foetal demise;
- parturient canal infections;
- bleeding associated with placenta previa;
- premature placenta detachment;
- possible miscarriage in 1 or 2 trimester of pregnancy;
- late toxicosis (3 trimester of pregnancy).
Proventil, released in aerosol form, when administered in therapeutic doses does not cause side effects.
Oral administration described in compliance with dosing instructions is rarely accompanied by undesirable side effects.
If you exceed one-time or daily dose of salbutamol, as well as in patients with hypersensitivity to stimulants β2-adrenergic receptors, the most significant side effects are fingers or hands tremors, inner trembling, increased tension.
In case of significant excess of therapeutic doses or special sensitivity, patient may experience:
- transient expansion of peripheral blood vessels;
- moderately severe tachycardia;
- muscle cramps;
Very rarely there is angioneurotic edema, manifested as:
- skin rash;
- other allergic reactions;
Instructions for Proventil Use
For patients older than 12 years, daily dose intended for oral dosage is from 6 to 16 mg. It is recommended for 3-4 receptions. In cases when necessary, it is allowed to increase daily dosage of 32 mg with multiplicity of application – 4 times a day.
Children aged 6 to 12 years are shown 2 mg 3 or 4 times a day, for patients of 2 to 6 years, optimal dose – 2.1 mg with multiplicity of application – 3 times a day.
Inhaled dose of Proventil for asthma depends on dosage form of medication assigned. In accordance with instructions for use, Proventil Aerosol is indicated for relief of bronchospastic syndrome or asthma attack. Adults usually are recommended spray administered 0.1-0.2 mg, children – 0.1 mg.
Multiplicity of procedures depends on particular clinical situation and indication.
In order to prevent physical strain associated with asthma attacks before physical exercise Proventil generic aerosol is administered at a dose of 0.1 mg for adults – 0.2 mg. The highest daily dose – 0.8 mg (equivalent to 8 inhalations).
This means, manufactured in form of powder, should be applied in similar pattern, but with corresponding dose doubling.
The solution is used for inhalation in dose of 2.5 mg 3 or 4 times per day. If appropriate, dose is permitted to increase up to 5 mg for the same multiplicity of applications.
Instructions for Proventil Inhaler Use
Before using inhaler, you should check it on working capacity. This procedure is also recommended in case if patient did not use it for some time.
It is necessary to remove inhaler cap and make sure that exit tube is not clogged with dust or dirt.
Hold can in upright position, place your thumb under bottom, and index – on the upper part, then it is necessary to shake the can several times up and down.
After deep breath (inhaling recommended without voltage), should tilt head back up and hold tight lips exit tube inhaler.
You should make slow deep breath, at the same time press by index finger (in the first third of inspiration). And you should continue breathing slowly.
After removing exit tube from mouth spray, it is necessary for 10 seconds (or as much as possible without pressure) to hold breath, then exhale slowly through your nose.
If you want to take more than one dose of Proventil, after the first inhalation stand for about a minute and then repeat all steps above (starting from the second paragraph). After procedure completion you should close spray cap.
At the time of drug release dose you should not be rushed, for maximum effect it is necessary to inhale the air as slowly as possible.
How to Clean Inhaler?
Clean inhaler should be carried out at least once a week. The balloon is removed from plastic casing, after which the case and the cap should be washed with warm water (not hot!).
Washed details should be carefully dried without the use of heating devices. Thereafter, the balloon is again placed into the case and closed the cap.
Do not dip metal canister into water.
Symptoms of Proventil overdose are:
- expansion of peripheral vascular disease;
- nausea and vomiting;
- ventricular flutter;
- lowering blood pressure indicators;
- muscle tremors;
- hypoglycemia transforming into hyperglycosemia.
Treatment involves drugs withdrawal prescribed to patient cardioselective β-blockers and symptomatic therapy.
If there is suspicion of salbutamol overdose, it is necessary to keep under constant supervision serum potassium concentration.
When using Proventil inhalers for asthma in combination with non-cardioselective β-blockers may mutual inhibition of therapeutic effects. In combination with theophylline may increase risk of arrhythmia and tachycardia (particularly supraventricular extrasystole).
In combination with diuretic, glucocorticosteroid drugs and xanthine derivatives risk of hypokalemia increases.